Main Villains and Antagonists only please. Feel free to add your own to list.
http://www.ranker.com/list/best-video-game-villians-v1/brandoncalton,
Albert Wesker
Arthas Menethil
Carmen Sandiego
Dr. Eggman
Aka Robotnik
Ganon
Aka Ganondorf
King Koopa
AKA Bowser
Seifer Almasy
Sephiroth
Pac-Man ghost
Lavos
Chrono Trigger